Every entry below was independently verified against the primary source — not just checked for a working link, but read to confirm it actually says what it's cited for. Where our own research surfaced a mismatch between a claim and its source, we corrected the claim on the page in question rather than publish a citation that doesn't hold up; see How We Source Claims. This bibliography currently covers the sourced claims already published across the site and will grow as new investigations are added.

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Topic

Evidence & Claims

The evidence behind What the Label Doesn't Tell You and the How to Read a Health Claim research guide.

Peer-Reviewed Study

The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers

The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group · New England Journal of Medicine · 1994

The central case study of Book One. Found an 18% increase in lung cancer diagnoses and an 8% increase in deaths among smokers given beta-carotene — the opposite of the hypothesized protective effect.

Cited in: What the Label Doesn't Tell You, Health Claims guide

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Peer-Reviewed Study

Effects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular Disease

Omenn, Gilbert S., et al. (CARET) · New England Journal of Medicine · 1996

Run independently of ATBC on a comparable population of smokers and asbestos-exposed workers, CARET reached the same negative conclusion — both trials stopped their beta-carotene arms early.

Cited in: What the Label Doesn't Tell You

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Peer-Reviewed Study

Beta-Carotene in Multivitamins and the Possible Risk of Lung Cancer Among Smokers Versus Former Smokers

Tanvetyanon, Tawee, and Gerold Bepler · Cancer · 2008

A pooled analysis across multiple trials and national brands, confirming the beta-carotene risk signal held up beyond any single study.

Cited in: What the Label Doesn't Tell You

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Government Report

Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cancer and Cardiovascular Disease: Recommendation Statement

U.S. Preventive Services Task Force

The federal task force's review found an overall 20% increased lung cancer risk associated with beta-carotene supplementation, concentrated among smokers.

Cited in: What the Label Doesn't Tell You

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Peer-Reviewed Study

Vitamin E Supplementation and Cardiovascular Events in High-Risk Patients

Yusuf, Salim, et al. (HOPE Study Investigators) · New England Journal of Medicine · 2000

Book One's second confirming example: early observational enthusiasm for a supplement reversing under a large, rigorous trial.

Cited in: What the Label Doesn't Tell You

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Federal Guidance

Information for Consumers on Using Dietary Supplements

U.S. Food and Drug Administration · FDA.gov

The agency's own consumer-facing guidance, used to confirm exactly what the FDA does and does not claim to verify before a supplement reaches a shelf.

Cited in: What the Label Doesn't Tell You

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Topic

Regulation

The evidence behind The Hollow Aisle and the The Regulatory Gap research guide.

Federal Law

Dietary Supplement Health and Education Act of 1994

Public Law 103-417, 103rd Congress

The foundational statute of this investigation — the law that classifies supplements as a food category and removed premarket safety and efficacy review.

Cited in: The Hollow Aisle, What Should Change

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Federal Guidance

Structure/Function Claims

U.S. Food and Drug Administration · FDA.gov

The regulatory definition distinguishing a structure/function claim from a disease claim — the line nearly all supplement marketing copy is written against.

Cited in: The Hollow Aisle, Regulatory Gap guide

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Government Data

CFSAN Adverse Event Reporting System (CAERS)

U.S. Food and Drug Administration · 2004–2021

The federal post-market surveillance data behind the 79,000+ adverse event figure cited throughout Book Two.

Cited in: The Hollow Aisle

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Federal Rule

Final Rule Declaring Dietary Supplements Containing Ephedrine Alkaloids Adulterated

U.S. Food and Drug Administration · 2004

The FDA's only use of its DSHEA authority to remove an entire ingredient category from the market — the regulatory record behind Case One in Book Three.

Cited in: The Hollow Aisle, Prove It

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Court Record

Pharmanex, Inc. v. Shalala

35 F. Supp. 2d 1341 (D. Utah 1999), rev'd, 221 F.3d 1151 (10th Cir. 2000)

The federal court case over whether red yeast rice containing concentrated lovastatin should be regulated as a drug — reversed on appeal, then won by the FDA on narrow grounds. The basis of Case Two in Book Three.

Cited in: The Hollow Aisle, Prove It

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Government Report

Final Decision on Cholestin

U.S. Food and Drug Administration · Docket No. 97P-0441 · 1998

The FDA's original administrative determination that Cholestin's concentrated drug compound disqualified it from supplement status.

Cited in: The Hollow Aisle, Prove It

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Government Data

Tainted Products Marketed as Dietary Supplements

U.S. Food and Drug Administration · Public Warning Database

The ongoing federal registry of products found spiked with undisclosed pharmaceutical ingredients — the evidentiary basis for Case Three in Book Three, built from the pattern rather than a single company.

Cited in: The Hollow Aisle, Prove It

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Federal Guidance

New Dietary Ingredient Notification Correspondence Regarding NMN

U.S. Food and Drug Administration · November 2022 and December 2025

The FDA's original 2022 exclusion determination for NMN and its 2025 reversal — the timeline behind Case Four in Book Three.

Cited in: Prove It

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Topic

Risk & Interactions

The evidence behind The Hollow Aisle and the When Natural Isn't Safe research guide.

Peer-Reviewed Study

Liver Injury From Herbals and Dietary Supplements in the U.S. Drug-Induced Liver Injury Network

Navarro, Victor J., et al. · Hepatology · 2014

The DILIN registry study behind Book Two's central risk finding — the rise from 7% to 20% of documented liver injury cases attributed to supplements, and the finding that 40% of implicated green tea extract products didn't list the compound on their label.

Cited in: The Hollow Aisle, Risk & Interactions guide

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Peer-Reviewed Study

Acute Heart Transplant Rejection Due to Saint John's Wort

Ruschitzka, Frank, et al. · The Lancet · 2000

The documented case of heart transplant rejection linked to a St. John's Wort–cyclosporine interaction — the clearest single interaction case in the entire investigation.

Cited in: The Hollow Aisle, Risk & Interactions guide

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Peer-Reviewed Study

Calcium Supplements With or Without Vitamin D and Risk of Cardiovascular Events

Bolland, Mark J., et al. · BMJ · 2010

The widely discussed meta-analysis behind the cardiovascular risk caveat attached to calcium supplementation, even where fracture-risk benefit is genuine.

Cited in: The Hollow Aisle, Prove It

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Topic

The Business

The evidence behind The Hollow Aisle and the Who Profits From Belief research guide.

Government Report

Staff Report on Multi-Level Marketing Income Disclosure Statements

U.S. Federal Trade Commission · 2024

A review of dozens of MLM companies' own income disclosures, finding most participants earned $1,000 or less annually — and that most participants earned nothing at all in at least 17 companies reviewed.

Cited in: The Hollow Aisle, The Business guide

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Research Report

AARP Foundation Study of Multilevel Marketing: Profiling Participants and Their Experiences in Direct Sales

DeLiema, Marguerite, et al. · AARP Foundation · 2018

Survey data corroborating the FTC findings — nearly half of MLM participants reported losing money once expenses were accounted for.

Cited in: The Hollow Aisle

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Topic

Physician & Pharmacist Training

The evidence behind The Hollow Aisle, Chapter 13.

Government Report

Nutrition Education in U.S. Medical Schools

National Academy of Sciences, Committee on Nutrition in Medical Education · National Academies Press · 1985

The original source of the 25-hour minimum nutrition education recommendation that U.S. medical schools have fallen short of for four decades.

Cited in: The Hollow Aisle

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Peer-Reviewed Study

Status of Nutrition Education in Medical Schools

Adams, Kelly M., et al. · American Journal of Clinical Nutrition · 2006

Survey data showing U.S. medical schools averaging 19–24 hours of nutrition education against the 25-hour recommended minimum.

Cited in: The Hollow Aisle

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News Report

Medical Schools Agree to Expand Their Nutrition Curriculum

National Public Radio · 2025

Reporting on the 2025 agreement by more than fifty U.S. medical schools to expand nutrition curricula to roughly 40 hours, confirming the training gap this investigation documents.

Cited in: The Hollow Aisle

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Topic

Chronic Disease Evidence

The evidence behind Prove It, Chapters 1–5.

Peer-Reviewed Study

Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

Manson, JoAnn E., et al. (VITAL) · New England Journal of Medicine · 2019

One half of the VITAL trial (25,871 participants) — found no significant reduction in cancer incidence from vitamin D supplementation.

Cited in: Prove It

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Peer-Reviewed Study

Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer

Manson, JoAnn E., et al. (VITAL) · New England Journal of Medicine · 2019

The companion VITAL result for omega-3 supplementation — no significant reduction in the composite cardiovascular endpoint, but a real 28% reduction in heart attack risk specifically.

Cited in: Prove It

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Peer-Reviewed Study

Ginkgo biloba for Prevention of Dementia: A Randomized Controlled Trial

DeKosky, Steven T., et al. (GEM) · JAMA · 2008

The largest trial ever run on ginkgo biloba for dementia prevention (3,069 participants) — found no protective effect.

Cited in: Prove It

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Peer-Reviewed Study

Saw Palmetto for Benign Prostatic Hyperplasia

Bent, Stephen, et al. · New England Journal of Medicine · 2006

A 225-patient randomized trial finding saw palmetto did not improve BPH symptoms compared with placebo.

Cited in: Prove It

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Peer-Reviewed Study

Effect of Increasing Doses of Saw Palmetto Extract on Lower Urinary Tract Symptoms

Barry, Michael J., et al. (CAMUS) · JAMA · 2011

A follow-up 369-patient trial testing escalating doses up to three times standard — reached the same negative conclusion at every dose.

Cited in: Prove It

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Book / Research

What Intelligence Tests Miss: The Psychology of Rational Thought

Stanovich, Keith E. · Yale University Press · 2009

The source of "dysrationalia" — research finding that general intelligence correlates only weakly with resistance to cognitive bias, central to Book Three's chapter on why smart people believe unproven claims.

Cited in: Prove It

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Research Report

Ephedra and Ephedrine for Weight Loss and Athletic Performance Enhancement: Clinical Efficacy and Side Effects

RAND Corporation · 2003

The independent scientific review commissioned ahead of the FDA's 2004 ephedra ban, cited in Case One of Book Three.

Cited in: Prove It

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Topic

International Comparison

The evidence behind Prove It, Chapter 9, and the What Other Countries Do research guide.

Government Report

Natural Health Products Regulations

Health Canada

The regulatory basis for Canada's premarket licensing system (Natural Product Number), evidence-scaled through a monograph model — one of two working alternatives behind the appendix's recommended framework.

Cited in: Prove It, What Should Change

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Government Report

Listed, Assessed Listed, and Registered Medicines Framework

Australian Therapeutic Goods Administration

The regulatory basis for Australia's three-tier, risk-based classification system — the second working alternative behind the appendix's recommended model.

Cited in: Prove It, What Should Change

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Legislation

Directive 2002/46/EC on Food Supplements

European Parliament and Council

The EU's positive-list framework — only listed vitamins, minerals, and forms may be used in a supplement, prohibited otherwise since August 2005.

Cited in: Prove It, International Comparison guide

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Government Report

Novel Foods Regulation (EC) No. 2015/2283

European Food Safety Authority

The EU's premarket safety evaluation requirement for any ingredient without a documented history of use before 1997.

Cited in: Prove It

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